Excessive Fibrinoid Deposition at the Utero-placental Interface is linked to Failure of Placental Separation in Accreta Placentation.

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The main histopathologic diagnostic criteria for the identification of placenta accreta for quite 80 years has been the finding of a right away attachment of the villous tissue to the superficial smooth muscle or adjacent to myometrial fibers while not interposing epithelial tissue. There are only a few elaborate histopathologic studies in pregnancies sophisticated by placenta accreta spectrum disorders and our understanding of the pathophysiology of the condition remains restricted. To prospectively appraise the microscopic changes employed in grading and to spot changes which may make a case for the abnormal placental tissue attachment. A total of 40 consecutive cesarean section excision specimens for maternity accreta at 32 to 37 weeks of gestation with a minimum of 1 histological slide showing deeply deep-seated villi were analyzed. Prenatal ultrasound examination enclosed placental location, myometrial thickness, subplacental property and lacunae. Megascopic changes of the lower section were recorded throughout surgery and areas of abnormal placental adherence were sampled for microscopic anatomy. Additionally, 7 excision specimens with placenta unchanged from the Boyd assortment at20.5 to 32.5 weeks were used as controls [1]. Samples from accreta areas